A novel sandwich ELISA method for quantifying CHI3L1 in blood serum and cerebrospinal fluid multiple sclerosis patients using sustainable photo-irradiated zero-valence gold nanoparticles

The widespread occurrence of chronic demyelinating MS presents a significant challenge for ongoing research aimed at comprehending its progression, diagnosis, and treatment. In our research, we have devised a novel approach to quantify CHI3L1 (Chitinase-3-like protein 1), which has emerged as a valuable biomarker in MS because of its involvement in inflammation, tissue remodeling, and immune response—crucial factors in regulating damaged nerve cells and preventing their accumulation in the br...